Novel coronavirus can be loaded more than 50,000 times in newborns, again raising the suspicion of mother-to-child transmission

Compared with the large number of elderly deaths caused by the novel coronavirus pandemic, the children group appears to be much safer.
But an unusual case of the novel coronavirus has baffled and shocked experts, who fear that an entirely new variant of the novel coronavirus makes infants and children “susceptible.”

Among the more than 2,000 newly infected children being treated at Children’s National Hospital in Washington, D.C., a newborn has caught the attention of health care workers.
Unlike most infected children, this child was very sick.
But what was really surprising was that her viral load was 51,418 times higher than the average of other pediatric patients.

Even more “shocking,” when sequencing the baby’s novel coronavirus gene, doctors found not only a D614G mutation in the virus, but also a never-before-seen N679S mutation.
Roberta DeBiasi, the hospital’s director of infectious diseases, told The Washington Post that while it’s impossible to draw any conclusions from a single case, this one is “a wake-up call” for everyone.

[Caution 1]

Variant novel coronavirus frequently appears

Infections among infants and children have soared

“It could be a coincidence.
But if the number of viruses in a patient is increasing exponentially, and it’s a completely different variant, then the association can be very strong.”
Speaking about the newborn with the virus mutation, Roberta de Biassi said, but added that no conclusions about the new variant strain could be drawn from a single patient.
There may be a high viral load in newborns or an underdeveloped immune system, but this case is “alarming” and raises important questions about how a new variant of novel coronavirus might affect children.

Alan Beggs, a genomics specialist at Children’s Hospital Boston, says there is no evidence that the new or other novel coronavirus variants make children sicker or cause more severe symptoms.
But because children are not eligible for the vaccine and the government is planning to allow schools to start again, this is crucial.

Novel coronavirus loads more than 50,000 times in newborns, according to futurism science

“The takeaway message is that we as a nation or society have done a poor job of identifying worrisome changes in the evolving novel coronavirus, and this is just evidence that we need to change more.”
‘said Alan Beggs.

While there is no evidence that the new variant, N679S, or the others first discovered in Britain, South Africa and Brazil, are any more dangerous to children, there has been an “unusual” recent surge of infections among children in countries around the world, The Washington Post reported.

Health officials in Britain say they are monitoring for an unusual surge in infections among children ages 6 to 9, which is disproportionate to their proportion in the population.
In Italy, officials in the northern town of Colzano have been baffled by a similar spike in cases among schoolchildren and even younger children.

On February 9, the British Medical Journal published an article pointing to a sharp increase in the number of new crown infections among young people in Israel, with more than 50,000 children and adolescents testing positive in January, far exceeding the number of young people infected in Israel during the first and second waves.

In the United States, several major medical centers reported a spike in pediatric hospitalizations over the New Year holiday, similar to that seen in adults.
In January and February of this year, there was a surge in cases of multisystem inflammatory syndrome (MISC) in children, a rare complication of the new crown.

De Biassi said more MISC patients needed intensive care level support than last year.
Last year about 40 to 60 percent of patients needed to be sent to intensive care units; now it’s closer to 90 percent.
However, some hospitals say they have not noticed the trend.

[Caution 2]

“Lonely cases” keep cropping up

Again causing the new crown through mother-to-child transmission doubts

De Biassi and other authors also note that this particular N679S mutation appears to be related to how the virus enters the body.
It did not say whether the virus in this case was transmitted vertically from mother to child or through exposure.

In fact, whether novel coronavirus can be transmitted vertically from mother to child has been the focus of scientific discussion for nearly a year.

As previously reported by Red Star News, on March 26, 2020, two studies were published online in the Journal of the American Medical Association (JAMA) to present and investigate antibodies in infants born to mothers with CoviD-19.
One of the papers showed that the newborns of mothers diagnosed with Covid-19 had elevated antibody levels two hours after birth, including elevated IgM levels, indicating that the newborns had been infected in the womb.

▲ Scientists say they need to know whether the novel coronavirus variant makes children sicker or causes more severe symptoms.
Photo: Daily Mail

On July 14, 2020, the international academic journal Nature Communications published a research paper titled “Novel coronavirus infection via placenta”, conducted by the University Hospital of Thackeray in Paris.
The paper presents evidence of a case in which a mother who tests positive for novel coronavirus may pass the virus to her baby through the placenta.

On July 22, last year, however, Dr Anhui major medical microbiology teaching and research section QuMingSheng accept red star journalist, said in an interview will be coronavirus is currently considered respiratory viruses, and generally does not cause respiratory virus viremia, also almost cannot be transmitted through blood, “article in Nature (Nature – communication), or a rigorous and through the peer review, but this essay is transmitted through the placenta newborn case, cannot explain will be coronavirus through mother-to-child vertical transmission.
“More samples or animal models are needed to prove this.”

On December 22, 2020, a new study published online in the Journal of the American Medical Association (JAMA) shows that pregnant women who get new infections in their third trimester appear to be less likely to transmit the virus to their fetuses.
A study of 127 newborns in the Boston area between April and June 2020 found that 64 of the mothers were infected with varying levels of novel coronavirus, but none of the newborns were infected, the study said.
However, study author Dr. Andrea Edlow, a specialist in maternal and infant medicine, noted that the results are not conclusive, only that if the mother was infected during pregnancy, the chances of the baby being born with an active infection still appear to be relatively low.

▲ The Times of Israel reported on February 16 that Israel suspected the first case of a fetus infected through the mother’s placenta

However, according to the Times of Israel reported on February 16, Israel has suspected the first case of a fetus infected through the mother’s placenta.
A 25-week-old pregnant woman infected with Novel coronavirus was found to have the virus in a stillborn fetus, the report said.
“The fetus was infected through the placenta and certainly (we can say) died from novel coronavirus,” said Dr. Tal Brosh, head of infectious diseases at Ashdod Yasuta Hospital.

Currently, such cases are rare worldwide, with only a handful of documented cases in which mothers have infected their unborn children.
Therefore, whether novel coronavirus is transmitted vertically from mother to infant has not been determined so far.

What is clear, however, is that fetuses can acquire antibodies against Novel Coronavirus from their mothers.
The mother’s new crown antibodies can cross the placenta, potentially protecting the fetus from infection, according to a study published today in the journal JAMA Pediatrics.

The researchers analyzed blood samples from more than 1,470 pregnant women, and 72 of the 83 women who had antibodies against Novel coronavirus at delivery also had antibodies in their newborns.
This suggests that these babies have acquired passive immunity.
The researchers said the number of antibodies passed to the baby largely depended on the type and amount of antibodies in the mother’s body, as well as how long the mother had been infected with novel coronavirus during pregnancy.

Now, researchers hope to further investigate whether vaccinating pregnant women can provide similar protection for newborns.